If you’re insistent on trying it, it’s wise to first grease up a toe or a finger to see how it reacts. And because nitroglycerin gels are applied topically, the side effects may be transferred to your partner, too. Other serious side effects include methemoglobinemia, which can lead to seizures, cyanosis, and heart arrythmias, as well as bleeding and dermatitis on the penis. Men with heart disease or low-blood pressure shouldn’t use them. Murphy, MD, a professor of urology at Northwestern University’s Feinberg School of Medicine. “Nitroglycerin medications can result in a sudden and serious loss of blood pressure,” says Adam B. Like any med, the gels have their share of side effects. Lipshultz cautions that any off-label nitroglycerin use should be strictly supervised by a doctor. But the penis is a tricky place for experimentation and Dr. Larry Lipshultz, MD, Men’s Health advisor and a professor of urology at Baylor College of Medicine, says some doctors might be willing to prescribe it for “off label” use. For example, Rectiv is a topical hemorrhoid cream that’s 0.4 percent nitroglycerin (that’s twice as strong as the gels studied for erectile dysfunction). Still, some nitroglycerin gels are available with a prescription for medical conditions other than ED. 25 Foods That Might Help You Stay Erect.Nitroglycerin has been used as an active ingredient in many medications for more than a century, most often to treat high blood pressure and chest pain, but scientists have begun to study the chemical’s effectiveness for treating ED. In other words, the gel helps you get hard and stay hard. Nitroglycerin also releases nitric oxide, a compound that acts as a neurotransmitter that activates the nerves, helps relax the smooth muscle cells, and reduces the “outflow” of blood from the penis. Nitroglycerin gels stimulate erections by dilating blood vessels, allowing for more blood to enter the penis.

“Nitro gels make sense because they’re more powerful than pills and can be applied right to where you need them to work,” says New York-based urologist Elizabeth Kavaler, MD, a Men’s Health advisor. Unlike the little blue pills-which often require hours to work and have to be taken on an empty stomach-topical nitroglycerin gels and creams are rubbed directly onto the penis and begin working within minutes. And you're probably wondering where to get them. If you’re one of the 30 million men in the United States experiencing erectile dysfunction (ED), you’ve probably heard of nitroglycerin gels.

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